butalbital acetaminophen caffeine half life

Instruct patient to take medication exactly as directed.Medication should be discontinued gradually after long-term use to prevent withdrawal symptoms.

Analgesic is more effective if given before pain becomes severe. Regularly administered doses may be more effective than prn administration.Explain therapeutic value of medication before administration to enhance the analgesic effect.Potential Nursing DiagnosesAcute pain (Indications) Chronic headaches from overmedication are difficult to treat and may require hospitalization for treatment and prophylaxis. Frequent, chronic use may lead to daily headaches in headache-prone individuals because of physical dependence on caffeine and other components. Most patients who receive butalbital compound for pain do not develop psychological dependence. This should not prevent patient from receiving adequate analgesia. Prolonged use may lead to physical and psychological dependence and tolerance.Assess type, location, and intensity of pain before and 60 min following administration.Route/DosageĬapsules: 50 mg butalbital/300 mg acetaminophen/40 mg caffeine, 50 mg butalbital/325 mg acetaminophen/40 mg caffeine, 50 mg butalbital/500 mg acetaminophen/40 mg caffeine Cost: Generic - 50 mg/325 mg/40 mg $ 119.95 / 100 In combination with: codeine Rx. John’s wort may ↓ barbiturate effect.Concurrent use of kava kava, valerian, skullcap, chamomile, or hops can increase CNS depression. MAO inhibitors, felbamate, primidone, and valproic acid may prevent metabolism and increase the effectiveness of butalbital.St. Interactions Drug-Drug interactionAdditive CNS depression with other CNS depressants, including alcohol, antihistamines, antidepressants, opioid analgesics, and sedative/hypnotics.May increase the liver metabolism and decrease the effectiveness of other drugs including amiodarone, benzodiazepines, bupropion, calcium channel blockers, carbamazepine, citalopram, clarithromycin, cyclosporine, erythromycin, fluoxetine, fluvoxamine, glipizide, hormonal contraceptives, losartan, methadone, mirtazapine, nateglinide, nefazodone, nevirapine, phenytoin, pioglitazone, promethazine, propranolol, protease inhibitors, proton pump inhibitors, rifampin, ropinirole, rosiglitazone, selegiline, sertraline, tacrolimus, theophylline, venlafaxine, voriconazole, warfarin, and zafirlukast. Adverse Reactions/Side Effects Central nervous system Geriatric patients are at increased risk for side effects (dosage reduction recommended) Children <12 yr (safety not established). Use Cautiously in: History of suicide attempt or drug addiction Chronic alcohol use Severe hepatic or renal disease Severe cardiovascular disease Patients concomitantly receiving other CNS depressants Geriatric: Appears on Beers list.

Butalbital acetaminophen caffeine half life